A new study suggests that a bacteria called Mycobacterium vaccae may help combat symptoms of anxiety and depression. The bacteria has been shown to dampen inflammation and improve mood in mice. The scientists are currently pursuing Investigational New Drug (IND) status for this strain. If approved, it could be given to people who suffer from PTSD, as well as soldiers preparing for deployment and emergency room workers.
Mycobacterium vaccae Shows Promise in Treating Anxiety
A study from the University of Colorado Boulder looked at how M. vaccae affected the brain. Researchers found that rats exposed to early life stress had altered gut microbiota, as well as increased levels of systemic immune responses and plasma corticosterone.
These findings suggest that early life stress increases the risk of developing pro-inflammatory diseases mycobacterium vaccae probiotic. The researchers suspected that M. vaccae’s pro-inflammatory properties may be related to increased intestinal permeability, which could allow Gram-negative bacteria components to cross the intestinal barrier.
Their findings suggest that Mycobacterium vaccae may be implicated in the inflammatory state that is prevalent in people suffering from depression.
Although preclinical studies indicate that the strains of Mycobacterium vaccae may have psychobiotic properties, they need more testing before they can be prescribed to patients.
Researchers are focusing on strains that secrete GABA, tryptophan, and short-chain fatty acids. These strains impact the HPA and the inflammatory response pathway. In addition, abnormalities in these parameters have been associated with stress disorders.